The only thing that would make me hesitate is if I parked my car on the street. Plowing isn't exactly the quickest affair here in Milwaukee but once they do plow it can be a nightmare to get cars out of spaces if they aren't all wheel drive.
With that said I've lived with a front wheel drive, a rear wheel drive and now an all wheel drive car in Milwaukee and haven't had any problems. I've always parked in a garage and generally haven't been afraid to go out in the snow, even on all seasons. If you grow up around snow and have any sense about you then it generally isn't that difficult to manage.