Done that drive a few times myself. Pay special attention around Va and Delaware. They live off of out of state ticket revenues. Also, radar detectors are illegal in Va, dont get caught with one. If they see it mounted they will pull you over.
Stay at a decent place off 95 and try to park near the front in the lights where there is more traffic. Cars can be fucked with by vermin along the route. They know that vacationers with money and stuff in their cars stay there. Take your electronics in the room with you and anything else valuable.
After an hour or so driving a stick is second nature, especially in flat Fl.
Avoid the loop around DC, traffic can be brutal.
Take the Chespeake tunnel, it saves time.
I've gotten mislabled gas at some of the no brand stations along 95. Stay with the known names and get 93oct.
Congrats on your new car and have a good trip.