Obviously which Formula had the best sound is arguable. But if there was a vote, mine would go to the early '50's 1.5L BRM V16 (second would be the late '60's 3.0L Matra V12 - prettiest too, third would be the '65 1.5L Ferrari Flat 12).
Whenever the formula has changed - there have been the cries (mine included) that it's been ruined. Amazingly it still draws the enthusiast.
www.youtube.com/watch?v=fZMPDCNyQxE